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Pregnancy Outcomes After Maternal or Paternal Exposure to Tofacitinib Across Clinical Programs
Uma Mahadevan1, María Chaparro2, Michelle Segovia3
1Colitis and Crohn's Disease Center, University of California San Francisco, San Francisco, California, USA.
Introduction:
This analysis reports updated pregnancy outcomes after tofacitinib exposure in patients with immune-mediated diseases.
Methods:
Pregnancy/partner pregnancy cases from interventional studies were identified in Pfizer safety database through March 2023.
Results:
Of 184 pregnancies reported, 85 were maternal exposure events: 46 healthy newborns, 12 medical terminations, 1 fetal death, 1 congenital malformation, 14 spontaneous abortions, and 11 pending/lost to follow-up. There were 99 paternal exposure events: 67 healthy newborns, 1 fetal death, 9 spontaneous abortions, and 22 pending/lost to follow-up.
Discussion:
Outcomes of maternal/paternal tofacitinib exposure were similar to those expected in the general population; tofacitinib should not be used during pregnancy unless clearly necessary.
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