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Updated: Jul 24, 2026

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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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Comparative Efficacy of Two Hemostatic Agents in Post-Extraction Bleeding Control Following Mandibular Third Molar
Giovanna Pesce1, Suelen Cristina Sartoretto2,3, Rodrigo Figueiredo de Brito Resende2,3
1Post-Graduation Program in Dentistry, Fluminense Federal University, Niteroi 24220-140, Brazil.
Journal of Functional Biomaterials
|September 26, 2025
Summary
Surgifoam and Hemospon, gelatin hemostatic sponges, showed equal effectiveness in controlling bleeding, promoting soft tissue healing, and managing pain after third molar extraction surgery.
Area of Science:
- Oral Surgery
- Biomaterials
- Wound Healing
Background:
- Absorbable hemostatic sponges are vital for surgical bleeding control.
- Surgifoam and Hemospon, derived from porcine gelatin, are commonly used in oral surgery.
Purpose of the Study:
- To compare the efficacy of Surgifoam and Hemospon in bleeding control, soft tissue healing, and postoperative pain following mandibular third molar extractions.
Main Methods:
- A randomized, double-blind, split-mouth study involving 25 volunteers.
- Sockets were filled with either Hemospon or Surgifoam post-extraction.
- Evaluations included bleeding (Souto and Mühlemann scales), soft tissue healing (Brancaccio scale), and pain (Visual Analog Scale).
Main Results:
- Both sponges demonstrated comparable outcomes in bleeding control, soft tissue healing, and pain reduction.
- No statistically significant differences were found between Surgifoam and Hemospon for any evaluated parameter (p > 0.05).
- High rates of complete healing (90%) were observed by day 14 in both groups.
Conclusions:
- Hemospon and Surgifoam are equally effective hemostatic agents in oral surgery.
- These findings support the use of both sponges for managing post-extraction sockets, particularly after third molar removal.
- Further research can guide clinical decisions regarding these specific hemostatic materials.

