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Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
[Epidemiology of measles in Japan]
1Kanagawa Prefectural Institute of Public Health.
Abstract:
As of May 2025, measles outbreaks have been occurring worldwide. Japan has reported the highest number of cases since the beginning of the COVID-19. Unvaccinated measles cases are highly contagious and at high risk for serious illness, so it is important to ensure that children receive the live attenuated measles-rubella (MR) vaccine as soon as they become one year old. Additionally, the second routine immunization coverage rate must be raised to 95% or higher among five-to six- year-old children (one year before entering elementary school). For elementary school students and older individuals, it is important to check the vaccine records showing two doses of a measles-containing vaccine administered at or after one year of age. Those born on or after April 2, 1990, had the opportunity to receive two routine vaccinations; however, their records must be checked to confirm receipt. We also recommend checking vaccination records before traveling abroad. Additionally, rapid active epidemiological surveillance should be conducted in the event of a single measles case. Emergency vaccination within 72 hours of exposure for susceptible individuals may prevent the disease. For individuals ineligible for vaccination, health insurance covers the prevention of severe disease through an intramuscular injection of human immunoglobulin within six days of exposure. The most important measure is prophylaxis prior to exposure to the measles virus.
Insights
Measles outbreaks are rising globally. Ensure children receive the measles-rubella (MR) vaccine at one year old and confirm two doses for older individuals to prevent serious illness.
Area of Science:
- Public Health
- Epidemiology
- Immunization
Background:
- Global measles outbreaks are increasing, with Japan reporting high case numbers since COVID-19.
- Unvaccinated individuals are highly contagious and at risk for severe measles complications.
Purpose of the Study:
- To emphasize the importance of timely measles-rubella (MR) vaccination and confirm immunization status.
- To outline strategies for preventing measles transmission and managing potential outbreaks.
Main Methods:
- Reviewing current measles outbreak data and vaccination recommendations.
- Analyzing strategies for achieving high immunization coverage rates.
- Recommending epidemiological surveillance and post-exposure prophylaxis.
Main Results:
- High measles incidence necessitates prompt vaccination and confirmation of immunity.
- Achieving 95% second-dose MR vaccine coverage in preschoolers is crucial.
- Pre-exposure prophylaxis and rapid response are key to controlling outbreaks.
Conclusions:
- Prioritize childhood MR vaccination and verify immunization records for all age groups.
- Implement robust surveillance and emergency measures to curb measles spread.
- Prophylaxis before measles virus exposure is the most effective preventive strategy.
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