Related Experiment Video
Updated: Jan 16, 2026
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.5K
Inflammation in Obstructive Sleep Apnea: A Global Bibliometric Perspective
Haixia Fan1, Huiyan Niu2, Bomeng Zhao2
1Department of Sleep Center, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, People's Republic of China.
Nature and Science of Sleep
|September 29, 2025
Summary
This bibliometric analysis maps global research on inflammation in obstructive sleep apnea (OSA), revealing key contributors and trends. Future research should focus on biomarkers and anti-inflammatory therapies for improved patient outcomes.
Area of Science:
- Bibliometrics
- Sleep Medicine
- Immunology
Background:
- Obstructive sleep apnea (OSA) is increasingly recognized as a systemic disorder.
- Inflammation plays a pivotal role in OSA pathophysiology and comorbidities.
Purpose of the Study:
- Conduct the first comprehensive bibliometric analysis of global research on inflammation in OSA.
- Map knowledge structures, identify influential contributors, and highlight emerging research trends.
Main Methods:
- Retrieved publications on OSA and inflammation from Web of Science Core Collection (1996-2025).
- Analyzed 2,075 articles and reviews using bibliometric tools (CiteSpace, VOSviewer, bibliometrix R package).
- Examined citation frequencies, co-citation networks, and collaboration patterns.
Main Results:
- Publication growth rate of 12.11% annually, with China and the US as leading contributors.
- Identified key institutions (Harvard, University of Chicago, INSERM) and authors (Gozal D, Kheirandish-Gozal L, Khalyfa A).
- Highlighted research focuses on cardiovascular disease, metabolic syndrome, neuroinflammation, and therapies (CPAP, surgery); emerging topics include gut microbiota and vitamin D.
Conclusions:
- Research on inflammation in OSA is evolving towards clinical management and interdisciplinary exploration.
- Future priorities include biomarker discovery and anti-inflammatory therapeutic strategies.
- Findings provide a roadmap for targeted research and clinical translation to improve patient outcomes.
More Related Videos
Related Concept Videos
01:21Sleep Apnea
481
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
481
01:17Other Pulmonary Disorders
1.5K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.5K
01:30Tonsillitis I: Introduction
1.8K
Tonsillitis is inflammation of the tonsils, which are two lymphoid tissue masses at the back of the throat. This condition can cause discomfort and irritation in the throat.
Etiology
Three primary contributing factors have been identified.
Etiology
Three primary contributing factors have been identified.
1.8K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
3.6K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
3.6K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:22Chronic Obstructive Pulmonary Disease
2.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.3K