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The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
Published on: April 28, 2015
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From organ to system: multiorgan-on-a-chip platforms as next-generation biomedical simulators
Chen Chen1,2,3, Lin Zhou2, Ni Kou1,3
1School of Stomatology, Dalian Medical University, Dalian 116044, People's Republic of China.
Biofabrication
|September 30, 2025
Summary
Multiorgan-on-a-chip (multi-OoC) systems mimic human physiology for better preclinical research. These advanced bioengineered platforms enhance disease modeling and drug discovery, bridging the gap to clinical translation.
Area of Science:
- Bioengineering
- Biomedical Research
- Physiology
Background:
- Human organs interact dynamically, crucial for physiological processes.
- Traditional cell and animal models inadequately replicate in vivo physiology and pathology.
- Innovative platforms are needed to bridge preclinical research and clinical translation.
Purpose of the Study:
- To elaborate on the necessity of developing multiorgan-on-a-chip (multi-OoC) systems.
- To delve into the structural design and biomanufacturing strategies of multi-OoC.
- To highlight applications, challenges, and prospects of multi-OoC in personalized medicine.
Main Methods:
- Reviewing the development and necessity of multi-OoC systems.
- Analyzing structural design and biomanufacturing strategies.
- Examining applications, challenges, and future prospects in biomedical research.
Main Results:
- Multi-OoC systems offer precise control over cellular microenvironments.
- They recapitulate organ-level functions and interorgan crosstalk.
- These systems provide novel opportunities for disease modeling, drug discovery, and personalized medicine.
Conclusions:
- Multi-OoC systems are essential for advancing preclinical research and clinical translation.
- Standardization of operating procedures and model validation are key challenges.
- Multi-OoC holds significant promise for personalized medicine applications.
