Application of Amniotic Membrane to Effectively Treat Chronic Cervicitis: A Case Series

Chronic cervicitis is a clinical syndrome characterized by persistent inflammation of the cervical epithelium. Women with chronic cervicitis often experience symptoms such as vaginal discharge, dyspareunia, post-coital bleeding, and fatigue. The treatment of chronic cervicitis is controversial, particularly in cases where no specific pathogenic agent be identified. Natural wound dressings with human amniotic membranes have been successfully used in tissue healing procedures. Thus, this approach may be a potential therapeutic option for patients suffering from chronic cervicitis. This case series reports on five women diagnosed with chronic cervicitis. These patients had negative Pap smears, human papillomavirus (HPV) typing tests, and colposcopic biopsies, indicating no infections or malignancies. Despite receiving oral antibiotics, their symptoms did not improve, leading to the decision to treat them with amniotic membrane. The cervix was assessed using a speculum, and amniotic membranes manufactured by Sinacell Company were inserted into the affected cervical areas. The patients were instructed to avoid sexual intercourse for one week and continue using oral antibiotics. At the follow-up, all patients significantly improved without any adverse events. Additionally, colposcopic examinations revealed that most patients showed improvement in cervical inflammation and bleeding. The amniotic membrane can assist women with chronic cervicitis by alleviating symptoms and enhancing the healing of cervical ulcers without complications.