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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

1.5K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Cross-reactivity00:42

Cross-reactivity

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Overview
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

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The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's...
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[Sensitization to aeroallergens in adults with allergic rhinitis in a tertiary care hospital in Mexico City].

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Related Experiment Video

Updated: Jan 16, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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[Hypocomplementemic urticarial vasculitis in SLE: between urticaria and autoimmunity].

Jacqueline Edith Mut Quej1, Paula Isabel Ramirez Molina2, Maria Isabel Saad Manzanera2

  • 1Unidad Médica de Alta Especialdad, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Intituto Mexicano del Seguro Social, Ciudad de México. jacquelinemut18@gmail.com.

Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|October 2, 2025
PubMed
Summary

Hypocomplementemic urticarial vasculitis (HUV) is crucial to consider in systemic lupus erythematosus (SLE) patients with persistent skin lesions. Early diagnosis and management of HUV are vital to prevent systemic complications.

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Urticarial vasculitis (UV) affects small blood vessels, presenting as persistent urticarial lesions (>24 hours) with leukocytoclastic vasculitis.
Keywords:
AutoimmunityHypocomplementemiaSystemic lupus erythematosusUrticariaVasculitis

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  • UV is classified into normocomplementemic (NUV) and hypocomplementemic (HUV) types, with HUV linked to systemic diseases like SLE.
  • The incidence of UV is approximately 0.5 per 100,000 person-years.