Indopexines A and B: Two Prenylated Isoindoline Alkaloids from the Fungus Aspergillus sp. TJ507
Yeting Zhang1, Qing Li2,3, Zhengyi Shi1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Abstract:
Indopexines A (1) and B (2), two prenylated isoindoline alkaloids, were isolated from Aspergillus sp. TJ507. Their structures were determined by extensive spectroscopic analysis, CASE algorithms, quantum 1H and 13C NMR DP4+, and electronic circular dichroism calculations. Structurally, 1 was the first examples of isoindoline alkaloids bearing a 6/5/5/6 ring based on the 2-oxa-10-azatetracyclo-[7.7.0.01,12.03,8]cetane core, while 2 featured an 5,20-bioxa-1-azapencyclo-[10.7.1.01,12.06,11.013,18]lcosane moiety. Furthermore, 1 displayed an inhibitory effect toward triple-negative breast cancer cells through the Rap1/PI3K/AKT signaling pathway.
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