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Dapsone 7.5% Gel Versus Trichloroacetic Acid Peels
Dalia A Atallah1, Sahar R Bestawy2, Sara A Abouelmajd3
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Background:
Acne vulgaris is a chronic and multifactorial skin disease that can occur during adulthood, with a negative impact on self-esteem. Dapsone is a common antibacterial and anti-inflammatory medication used to treat several skin conditions.
Objective:
Objectives were to compare efficacy, tolerability, and safety of dapsone 7.5% gel versus trichloroacetic acid peel TCA 20% in the treatment of acne vulgaris.
Materials And Methods:
Thirty patients with acne vulgaris participated in a split-face, comparative, quasi-experimental clinical study. Trichloroacetic acid peels 20% were applied to the right side of the participants' face every 2 weeks for 3 months. The participants were instructed to apply dapsone 7.5% gel once daily at night on the left side of the face for 3 months.
Results:
There was a little difference between the 2 treatments; however, both sides of the face showed a considerable decrease in lesion counts and the Global Acne Grading Score (GAGS) after treatment.
Conclusion:
The clinical effectiveness of trichloroacetic acid peeling and dapsone 7.5% gel was not significantly different in mild and moderate acne vulgaris. Dapsone 7.5% gel is more effective in treating inflammatory than noninflammatory lesions.
