Efficacy of Different Local Drug Delivery Systems in the Management of Peri-implantitis: An In Vivo Study

The purpose of the present study was to examine the efficacy of 3 various local drugs delivery methods in the treatment of peri-implantitis.

Forty-five participants with peri-implantitis cases were included in this investigation. All participants were randomly allotted to the following groups with fifteen subjects in each group, group I: Subjects with chlorhexidine chip placement, group II: Subjects with tetracycline (TC) fibers placement, group III: Subjects with minocycline microspheres placement. Plaque index (PI), gingival index (GI) and probing depth (PD) measurements were recorded at the time of screening, 1st month and 3rd months postintervention. Data gathered was statistically analyzed.

Mean gingival score at baseline and 3rd month were 1.82 ± 0.01 and 0.92 ± 0.12 for group I, 1.74 ± 0.02 and 0.84 ± 0.16 for group II and 1.78 ± 0.14 and 0.98 ± 0.06 for group III respectively. In group I the mean plaque score at baseline and third month were 1.90 ± 0.03 and 0.98 ± 0.12, group II were 1.86 ± 0.04 and 0.94 ± 0.02, group III were 1.80 ± 0.04 and 1.04 ± 0.16. The mean PD at baseline and third month were 5.30 ± 0.02 and 4.74 ± 0.06 in group I, 5.42 ± 0.02, 1st month was and 4.18 ± 0.08 for group II, and 5.26 ± 0.02 and 4.36 ± 0.09 in group III. There was a highly significant difference found (p < 0.001).

Within the limitations of this study, TC fibers group was superior in improving GI, PI and PD scores and effective in peri-implantitis management than chlorhexidine chip and minocycline microspheres group.

One benefit of using local delivery agents (LDA) is that they can transport large concentrations of antibiotics to the intended locations. However, their effectiveness can be limited by the continuous flow of saliva and gingival crevicular fluids. Longer implant retention is associated with a higher prevalence rate of peri-implantitis. Therefore, an effective modality to manage peri-implantitis is necessary owing to the fact that the number of implants is ever-increasing. How to cite this article: Sahoo N, Nedumgottil BM, Chakraborty S, et al. Efficacy of Different Local Drug Delivery Systems in the Management of Peri-implantitis: An In Vivo Study. J Contemp Dent Pract 2025;26(7):683-687.