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Updated: Jan 16, 2026

Syntheses, Crystallization, and Spectroscopic Characterization of 3,5-Lutidine N-Oxide Dehydrate
Published on: April 24, 2018
Syntheses of Pyrene-4,5-dione and Pyrene-4,5,9,10-tetraone
Omolola Balogun1, Besan Khader1,2, Tetyana Ignatova2
1Department of Chemistry, North Carolina A&T State University, Greensboro, North Carolina 27411, United States.
Abstract:
Improved gram scale synthesis procedures for the preparation of pyrene-4,5-dione and pyrene-4,5,9,10-tetraone are reported. Pyrene-4,5-dione has been synthesized using potassium persulfate as the oxidant and RuO2·nH2O as the catalyst in the biphasic CH2Cl2/H2O solvent mixture containing K2CO3 as the base. We also developed several procedures for multigram scale oxidation of pyrene-4,5-dione to pyrene-4,5,9,10-tetraone, eliminating the need for chromatographic purification of the poorly soluble tetraone product.
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