Genetic evidence for the correlation between relative nutrient intake and male reproductive health: a Mendelian
Shuangping Li1, Shuang Wang2, Zhinan Jing2
1Department of Urology, Second Hospital of Shanxi Medical University, People's Hospital of Lvliang City, Lvliang, Shanxi, China.
Background:
The relationship between the composition of dietary macronutrient intake and male reproductive health (MRH) has been a topic of interest in public health. This study aimed to evaluate the causal effects of dietary macronutrient composition on MRH.
Methods:
Data on the four relative macronutrients intake and seven MRH outcomes were obtained from large genome-wide association studies (GWAS) and FinnGen Biobank. Multiple MR (Mendelian Randomization) methods were utilized in our study, including inverse variance weighted (IVW), MR-Egger, weighted median (WM), and MR-pleiotropy residual sum and outlier (MR-PRESSO).
Results:
Our results revealed that a higher relative intake of carbohydrates (RC) was associated with a reduced risk of erectile dysfunction [OR = 0.43; CI = 0.18-1.00; p = 0.0049]. Additionally, a higher relative intake of fat was observed to be a risk factor for abnormal spermatozoa [OR = 19.98; CI = 1.16-345.25; p = 0.039]. The relative intake of sugar (RS) was positively correlated with levels of bioavailable testosterone [OR = 1.23; CI = 1.03-1.47; p = 0.022].
Conclusion:
These findings contribute to the evidence of a causal relationship between four relative macronutrients intake and MRH. However, further confirmation of these causal effects through clinical trials is warranted.
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