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Chronic hepatitis E: The neglected liver killer.

Chang-Yi Ji1, Meng-Meng Gu2, Lan Huang2

  • 1Anhui Province Key Laboratory of Immunology in Chronic Diseases, Research Center of Laboratory, School of Laboratory, Bengbu Medical University, Bengbu 233000, China.

Hepatobiliary & Pancreatic Diseases International : HBPD INT
|October 4, 2025
PubMed
Summary
This summary is machine-generated.

Hepatitis E virus (HEV) can cause chronic infections in immunocompromised individuals, potentially leading to liver fibrosis and cirrhosis. Early diagnosis and prevention are crucial due to limited treatment options.

Keywords:
Chronic hepatitis EHepatitis EHepatitis E virusImmunosuppression

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Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis E virus (HEV) infections can be acute or persistent.
  • Chronic hepatitis E is common in immunocompromised individuals, including organ transplant recipients, HIV-positive patients, and those with hematological malignancies.
  • Chronic HEV poses a significant risk for developing liver fibrosis and cirrhosis.

Purpose of the Study:

  • To review the epidemiology, clinical manifestations, diagnostics, and therapeutics of chronic hepatitis E.
  • To highlight the challenges in managing HEV in immunocompromised populations.

Main Methods:

  • Comprehensive PubMed searches were conducted up to September 2024.
  • Search terms included "immunocompromised," "solid organ transplant," "HIV," "hematological malignancy," and "hepatitis E virus."
  • References from key articles were manually reviewed to identify additional publications.

Main Results:

  • Immunocompromised individuals with HEV are at higher risk for chronic infection.
  • Chronic HEV can progress to liver fibrosis and cirrhosis.
  • Understanding and treatment of HEV remain limited, posing challenges for prevention and management.

Conclusions:

  • Chronic hepatitis E requires specialized clinical attention.
  • Identifying risk factors is essential for accurate diagnosis and effective prevention.
  • Improved monitoring, treatment, and prevention strategies are needed for immunocompromised individuals.