[Neuropathology of Argyrophilic Grain Disease]

Dementia is classified into various types with corresponding underlying pathologies, including Alzheimer's disease, dementia wiht Lewy bodies, and vascular dementia; final diagnosis is often possible only after a pathological examination during an autopsy. Furthermore, older adults often have comorbid pathologies that make clinical diagnosis even more difficult. While protein-targeted treatments are emerging, different dementia types have varying pathologies and prognoses, necessitating efforts to improve diagnostic accuracy while the patient is alive. To achieve this, autopsy diagnosis information must be correlated with clinical biomarker data.