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Related Concept Videos

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
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Related Experiment Video

Updated: Jan 16, 2026

Ultrasonographic Evaluation of Breast Cancer-related Lymphedema
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LYMPHOSCINTIGRAPHY IN LYMPHEDEMA.

Igor Iskra1, Tatjana Bogović Crnčić1,2, Neva Girotto1,2

  • 1Clinical Department of Nuclear Medicine, University Hospital Center Rijeka, Croatia.

Acta Clinica Croatica
|October 6, 2025
PubMed
Summary
This summary is machine-generated.

Lymphedema diagnosis and management can be challenging. Lymphoscintigraphy is a key nuclear medicine imaging technique for assessing lymphedema severity and guiding treatment, though standardization is needed.

Keywords:
Lymphedemalymphoscintigraphytechnetium Tc 99m-nanocolloid

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Area of Science:

  • Nuclear Medicine
  • Diagnostic Imaging
  • Lymphatic System Research

Background:

  • Lymphedema is a chronic condition resulting from impaired lymphatic transport, causing limb edema.
  • Current treatments are often long-term and yield unsatisfactory outcomes.
  • Surgical interventions are emerging as an option for lymphedema management.

Purpose of the Study:

  • To highlight the role of lymphoscintigraphy in diagnosing and managing lymphedema.
  • To discuss the application of lymphoscintigraphy in assessing disease severity and surgical outcomes.
  • To identify areas for improvement in lymphoscintigraphy standardization.

Main Methods:

  • Lymphoscintigraphy involves injecting technetium-99m labeled colloidal particles.
  • Imaging is performed using two-dimensional or three-dimensional gamma cameras.
  • The technique aids in differentiating lymphedema from other edematous conditions.

Main Results:

  • Lymphoscintigraphy is the preferred method for lymphedema diagnosis.
  • It assists in evaluating disease severity and the effectiveness of surgical treatments.
  • Semiquantitative methods for staging are used but lack standardization.

Conclusions:

  • Lymphoscintigraphy is a valuable tool in the lymphedema diagnostic workup.
  • Standardization of semiquantitative methods is crucial for consistent disease staging.
  • Further refinement of the procedure can improve lymphedema patient care.