Comparative Evaluation of Bone Regeneration in Third Molar Extraction Using Simvastatin Powder And Simvastatin Gel-A...

Area of Science:

• Oral surgery
• Biomaterials science
• Regenerative medicine

Background:

• Third molar extraction is a common surgical procedure.
• Bone regeneration is crucial for post-extraction healing.
• Simvastatin has shown potential in promoting bone growth.

Purpose of the Study:

• To compare the efficacy of simvastatin powder versus simvastatin gel in promoting bone regeneration after third molar extraction.
• To evaluate pain and wound healing post-extraction with simvastatin application.

Main Methods:

• A randomized, split-mouth, single-blinded trial involving 10 patients.
• Simvastatin (10 mg) in Gelfoam or as a gel was applied to extraction sockets.
• Radiographs (RVG) were analyzed for bone density (gray mean scale) at 1, 4, 8, and 12 weeks.
• Pain (VAS scale) and wound healing (Landry et al. scale) were assessed.

Main Results:

• Both simvastatin powder and gel demonstrated significant bone regeneration.
• Bone regeneration showed a significant increase, peaking at the 12-week mark.
• Simvastatin application positively influenced bone regeneration outcomes.

Conclusions:

• Simvastatin is recommended for use after third molar extraction to aid bone regeneration.
• Simvastatin gel is cost-effective but requires fresh preparation.
• Further research into sustained-release simvastatin delivery systems is warranted.