Plasmablastic Lymphoma of Maxilla in an Immunocompetent Adult

Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin's lymphoma often found in immunocompromised individuals, especially those with HIV. It features large neoplastic cells resembling plasmablasts and plasma cells, making it challenging to distinguish from plasma cell myeloma. PBL is difficult to diagnose, especially with small biopsies, and is associated with high relapse rates and mortality, even with treatment. A systematic diagnostic approach, including EBER status, helps confirm PBL. Awareness of its distinct features is vital for accurate diagnosis, particularly for dental professionals.