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Updated: Jan 15, 2026

Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Hydatidiform mole incidence in Lombardy, northern Italy, 2009-2022: continued decline or plateau?
Vittorio Parodi1, Sonia Cipriani2, Anna Cantarutti3,4
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan, Italy.
Introduction:
Hydatidiform mole (HM) incidence has shown contrasting temporal trends across different regions.
Methods:
We analyzed HM incidence in Lombardy, Italy, from 2009 to 2022. HM cases were identified through regional registry data.
Results:
A total of 1,131 HM cases occurred among 1,471,567 pregnancies, averaging 77 cases per 100,000 pregnancies. A significant decline was observed between 2009 and 2015 (p = 0.01), but no consistent trend emerged over the full period (p = 0.76). HM incidence was highest in women aged ≥46 (699.1/100,000) and <20 (107.6/100,000), and among women of Asian origin (110.4/100,000).
Discussion:
The study suggests that diagnostic practices and demographic shifts may have influenced HM trends, while also confirming persistent ethnic and age-related risk patterns.
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