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Updated: Jan 15, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
10-(4-Chloro-phen-yl)-4-[(4-fluoro-phen-yl)amino]-5-phenyl-5,8,9,10-tetra-hydro-pyrimido[4,5-b]quin-olin-6(7H)-one
Adesola A Adeleke1, Sizwe J Zamisa1, Bernard Omondi1
1School of Agriculture and Science, Discipline of Chemistry, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa.
Abstract:
The title compound, C29H22ClFN4O, crystallizes with one mol-ecule in the asymmetric unit. The pyrimidinyl and anilinyl moieties subtend a dihedral angle = 36.65 (5)°, while the di-hydro-pyridine and phenyl rings are approximately orthogonal [dihedral angles = 81.65 (7) and 89.95 (7)°]. The crystal packing reveals alternating C-H⋯π and C-F⋯π inter-actions forming corrugated two-dimensional sheets along the ac plane, which are further linked into a three-dimensional network through N-H⋯O and C-H⋯O hydrogen bonds and Cl⋯Cl inter-actions.
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