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Introducing the Descriptive Framework for Assessing Epidemiological Cross-National Transferability: Application to

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A new framework, FACT, enables reliable transfer of pediatric life-limiting condition prevalence data between countries. This method successfully estimated over 100,000 German children affected by such conditions.

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Area of Science:

  • Epidemiology
  • Global Health
  • Pediatric Health

Background:

  • Transferring epidemiological data between countries with limited information is challenging.
  • The application of pediatric life-limiting condition (LLC) prevalence rates across nations lacks a standardized method.
  • Existing methods for cross-national data transfer are unstructured and require validation.

Purpose of the Study:

  • To introduce the Descriptive Framework for Assessing Epidemiological Cross-National Transferability (FACT).
  • To provide a systematic, five-step approach for validating and executing the transfer of epidemiological prevalence estimates.
  • To assess the transferability of pediatric LLC prevalence data from England to Germany.

Main Methods:

  • Applied the FACT framework to German pediatric population data, using English prevalence estimates as a basis.
  • Adjusted official population statistics for both England and Germany for age and gender.
  • Compared key epidemiological indicators between the two countries to assess transferability.

Main Results:

  • Comparative indicators between England and Germany showed minimal deviation (<2.5/5 percentage points), supporting data transfer.
  • An estimated 103,566 German children and adolescents (65.30 per 10,000) were affected by life-shortening diseases in 2022.
  • Projections indicate between 107,934 and 138,817 cases by 2030.

Conclusions:

  • The FACT framework is a valuable tool for transferring epidemiological prevalence data across national borders.
  • The study successfully demonstrated the utility of FACT in estimating pediatric life-limiting conditions in Germany.
  • FACT's applicability is likely extendable to other epidemiological measures, including incidence rates.