Decoding the Spontaneous Resolution Nature of Gout: Molecular Crosstalk Between Immune Cells, Neutrophil
Jing Ma1,2, Xinru Liu1,2, Yuewang Li3
1Department of Rheumatology and Immunology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Abstract:
Gout, a prevalent rheumatic disorder, arises from purine metabolic dysfunction characterized by elevated uric acid levels, which culminates in hyperuricemia, crystallization of sodium urate, and subsequent deposition of these crystals in joints, synovium, and other tissues or organs. Spontaneous resolution of gout is defined as the self-resolution of acute gouty arthritis observed in some patients within 7-10 days without pharmacological intervention, with no residual sequelae. The mechanistic basis underlying this spontaneous resolution remains incompletely understood, involving a spectrum of biological entities including immune cells, RNA, neutrophil extracellular traps, inflammatory mediators, and pattern recognition receptors. This review synthesizes current research progress on the spontaneous resolution of gout, with the objective of delineating directions for future investigations.
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