Related Experiment Video
Updated: Jan 15, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Reliability of Pseudocontinuous Arterial Spin-Labeling in Ischemic Stroke and Comparison with Other Perfusion
Jéssica Borges Kroth1, Suzete N F Guarda2, Danny J Wang3
1From the Neurology Department (J.B.K.), FMUSP, Faculdade de Medicina, Universidade de Sao Paulo, SP, Brazil.
Background:
Pseudocontinuous arterial spin-labeling (pCASL) is a noninvasive, gadolinium-free MRI technique for assessing brain perfusion.
Purpose:
The test-retest reliability of pCASL-derived CBF measurements in ischemic stroke (IS) were evaluated and pCASL metrics were compared with those from DSC, CTP, and PET.
Data Sources:
Systematic searches were conducted in MEDLINE, EMBASE, and LILACS. Risk of bias and methodologic quality were evaluated using QUADAS-2 and Quality Appraisal for Reliability Studies tools.
Study Selection:
Eleven studies, encompassing 383 participants with IS were included.
Data Analysis:
Random-effects meta-analysis with inverse variance method and heterogeneity assessed using I 2 statistics were used.
Data Synthesis:
No PET studies were identified. Only 1 low-quality, high-risk-of-bias study assessed test-retest reliability, finding no significant differences in repeated absolute CBF measurements over time and excellent reliability across regions. Most studies comparing pCASL with DSC, and all comparing pCASL with CTP, had a low risk of bias. In the hyperacute phase of IS, pCASL and DSC showed no significant differences in infarct core relative CBF (95% CI, -0.11 to 0.13; I 2 = 0%) or hypoperfusion volumes (95% CI, -0.28 to 0.68; I 2 = 69%). Evidence on the comparability of pCASL with other DSC or CTP metrics was limited.
Limitations:
The small number of included studies prevented a meta-analysis for the primary outcome and limited conclusions for secondary outcomes.
Conclusions:
Robust conclusions about the test-retest reliability of pCASL or the comparability of metrics obtained with this technique and DSC, CTP, or PET in different phases after IS could not be drawn.
More Related Videos
05:23Author Spotlight: Noninvasive Cerebral Blood Flow Determination in Human Functional Brain Region for Diagnosis of Neurological Disorders
Published on: May 31, 2024
06:45Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
Published on: June 2, 2023