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PREVENTION IN THE PARENTAL GENERATION OF EXPOSED RATS: CONSEQUENCES OF TOXIC EXPOSURE TO CHROMIUM AND GAMMA
Y Iztleuov1, M Iztleuov2, A Dushmanov3
11Department of Radiology, Department of Radiology, NJSC "Marat Ospanov West Kazakhstan Medical University", Aktobe, Kazakhstan.
Background:
Toxic environmental exposures, such as chromium and gamma irradiation, are known to have detrimental effects on health. These exposures can lead to genetic alterations, developmental defects, and increased susceptibility to diseases in subsequent generations. This study aims to assess the effectiveness of Nettle and Burdock oils in preventing the negative effects of chromium and gamma radiation in rats directly exposed to these toxicants, focusing on oxidative stress, hormonal disruption, and reproductive health.
Methods:
An experimental study was conducted using 120 rats divided into 8 groups, administering Nettle and Burdock oils (0.5 mL/day) to investigate their potential protective effects against chromium and gamma radiation exposure. Parameters including blood and sperm analysis, oxidative stress markers, and reproductive health were assessed. Statistical analysis was performed using SPSS and Microsoft Excel.
Results:
The analysis showed that exposure to chromium and gamma rays had a considerable adverse effect on hormonal and sperm parameters. Testosterone levels were significantly lower in the γ (2.6±0.179) and Cr+6+γ (2.5±0.200) groups than in the control group (3.4±0.277). Estradiol levels were also reduced in exposed groups compared to controls (γ: 0.190±0.012; Cr+6+γ: 0.175±0.009 vs. control: 0.206±0.008). Additionally, sperm concentration was significantly lower in the Cr+6+γ group (4.7±0.366). Although the addition of Nettle and Burdock oils showed some improvement, the protective effects were minimal. No statistically significant differences were observed between treatment and exposed groups (p=1.000).
Conclusion:
The study demonstrates that chromium (Cr+6) and gamma irradiation significantly impaired hormonal, sperm health, and oxidative stress markers in the parental generation of exposed rats. While the addition of Nettle and Burdock oils showed some improvement, their protective effects were minimal. Statistical analysis revealed no significant differences between treatment groups, indicating limited efficacy of these oils in mitigating toxic exposure effects.
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