STUDY OF THE CHEMICAL COMPOSITION AND ANTIMICROBIAL ACTIVITY OF SUBCRITICAL CO₂ EXTRACT FROM EUPHORBIA HUMIFUSA WILLD

One of the priority areas of development in pharmacy is the study of local plants possessing antimicrobial activity. In this regard, determining the chemical composition of the CO₂ extract of Euphorbia humifusa Willd. with the aim of identifying new promising compounds with antimicrobial and antifungal activity is a pressing issue.

Using subcritical carbon dioxide extraction, 23 g of CO₂ extract of Euphorbia humifusa Willd. was obtained. To determine the potential use of Euphorbia humifusa Willd., we analysed the composition of the extract using GC-MS and the antimicrobial activity obtained by CO₂ extraction.

For the first time, a comprehensive study of the CO₂ extract from the aerial parts of Euphorbia humifusa Willd., collected during the flowering phase in the Bostandyk district of Almaty Region, was conducted. Using gas chromatography-mass spectrometry (GC/MS) with Wiley 7th edition and NIST'02 libraries, 47 components were identified.

The obtained CO₂ extract of Euphorbia humifusa Willd. can be used in pharmaceutical technology as a substance.