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Updated: Jan 15, 2026

Learning Modern Laryngeal Surgery in a Dissection Laboratory
Published on: March 18, 2020
Surgically Based Deintensification for Oropharyngeal Cancer: Current Concepts and Future Directions
Michael C Topf1, Thomas Kjaergaard2, Catherine Po Ling Chan3
1Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
None:
The paradigm for management of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (HPV + OPC) has evolved significantly in recent years. Following the interim futility analysis of NRG HN005, which reaffirmed standard-dose cisplatin-based chemoradiation as the standard of care in the nonsurgical setting, this review examines whether surgical approaches now represent the most viable path to treatment deintensification for appropriate patients with HPV + OPC. In this narrative review, we summarize data from key surgical deintensification clinical trials, discuss surgeon credentialing considerations, and review emerging technologies that may further refine patient selection and treatment response assessment.
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