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Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
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Now you serine, now you don't
Robert B Cameron1, Nia G Hammond1, Brandon Faubert1
1Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA.
Trends in Pharmacological Sciences
|October 12, 2025
Summary
Glioblastoma cancer cells show increased serine import for growth. Limiting serine uptake improved chemoradiation effectiveness in preclinical models, offering a potential new therapeutic strategy for brain tumors.
Area of Science:
- Oncology
- Cancer Metabolism
- Biochemistry
Background:
- Cancer cells reprogram metabolic pathways to fuel rapid proliferation.
- Glioblastoma (GBM) is an aggressive brain tumor with complex metabolic needs.
Purpose of the Study:
- To investigate tumor metabolism in glioblastoma patients.
- To explore the role of serine import in GBM growth.
- To assess the therapeutic potential of targeting serine uptake.
Main Methods:
- Direct examination of tumor metabolism in glioblastoma patients.
- Preclinical modeling of glioblastoma.
- Assessment of chemoradiation efficacy under conditions of limited serine uptake.
Main Results:
- Glioblastoma tumors exhibit significantly increased import of the amino acid serine.
- Restricting serine uptake potentiated the anti-tumor effects of chemoradiation in preclinical GBM models.
Conclusions:
- Serine import is a critical metabolic vulnerability in glioblastoma.
- Targeting serine uptake represents a promising therapeutic avenue to enhance chemoradiation efficacy for glioblastoma patients.
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