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Updated: Aug 10, 2026
04:17
DNA Virus Detection System Based on RPA-CRISPR/Cas12a-SPM and Deep Learning
Published on: May 10, 2024
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One-step naked-eye fluorescence detection of viruses using quantum dot-magnetic beads coupled with CRISPR/Cas12a
Ai-Xin Ma1, Qing Zhang1, Ming-Yu Zhang1
1State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry, and School of Medicine, Nankai University, Tianjin 300071, P. R. China. dwpang@whu.edu.cn.
Chemical Communications (Cambridge, England)
|October 14, 2025
Abstract:
This work constructs quantum dot-magnetic beads coupled with CRISPR/Cas12a for naked-eye detection of herpes simplex virus. The system integrates the high brightness of quantum dots and trans-cleavage activity of Cas12a, enabling rapid, simple, and accurate viral detection.
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