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Updated: Jan 15, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Tandem Nitro Reduction and Amide Condensation for the On-DNA Synthesis of Natural Product-Inspired Skeletons
Kangyin Pan1, Wentao Meng2, Ying Yao1
1Shanghai Institute for Advanced Immunochemical Studies, and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Abstract:
To facilitate the efficient incorporation of natural product elements into DNA-encoded libraries, a robust, metal-free, DNA-compatible protocol for nitro reduction and in situ amide condensation has been developed. This methodology utilizes DNA-conjugated (hetero)aromatic nitro electrophiles and simple amino acids as starting materials, enabling the efficient synthesis of structurally diverse DNA-conjugated skeletons that represent core motifs commonly found in bioactive molecules or natural products.
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