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Published on: July 6, 2016
A Multicomponent Chemistry for the Incorporation of N-Sulfonylguanidines into DNA-Encoded Libraries
Ying Yao1, Haozhi Jing1, Wanting Cui1
1Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Abstract:
To incorporate the N-sulfonylguanidine chemotype into DNA-encoded libraries (DELs), a cobalt-promoted, DNA-compatible N-sulfonylguanidine formation method has been developed. This method utilizes DNA-conjugated sulfonyl azides, isonitriles, and amines as readily accessible building blocks to enable modular, high-yielding synthesis of structurally diverse N-sulfonylguanidines, a privileged scaffold widely represented in biologically active small molecules.

