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Updated: Jan 15, 2026

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Targeting Genome Stability to Mitigate Human Aging and Disease.

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Maintaining a stable genome is crucial for health. Targeting DNA repair mechanisms may lower cancer risk and extend lifespan by improving genome integrity and cellular function.

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Area of Science:

  • Genetics
  • Molecular Biology
  • Gerontology

Background:

  • Genome stability relies on constant DNA repair.
  • Defects in DNA repair cause cancer and premature aging.
  • DNA damage accumulates with age, increasing cancer risk and cellular dysfunction.

Purpose of the Study:

  • Review emerging strategies for targeting genome maintenance.
  • Explore therapeutic potential for cancer risk reduction and lifespan extension.
  • Discuss approaches to limit DNA damage and enhance repair in normal cells.

Main Methods:

  • Literature review of genome maintenance mechanisms.
  • Analysis of DNA damage response (DDR) pathways.
  • Exploration of therapeutic targeting of DDR and senescence.

Main Results:

  • Targeting DNA repair offers therapeutic strategies for cancer.
  • Eliminating senescent cells may reduce inflammation.
  • Developing methods to limit DNA damage and augment repair in normal cells.

Conclusions:

  • Targeting genome maintenance can lower cancer risk.
  • Interventions may extend healthy lifespan by preserving somatic genome integrity.
  • Future strategies aim to enhance cellular function and longevity through genome maintenance.