Targeting Genome Stability to Mitigate Human Aging and Disease

Area of Science:

• Genetics
• Molecular Biology
• Gerontology

Background:

• Genome stability relies on constant DNA repair.
• Defects in DNA repair cause cancer and premature aging.
• DNA damage accumulates with age, increasing cancer risk and cellular dysfunction.

Purpose of the Study:

• Review emerging strategies for targeting genome maintenance.
• Explore therapeutic potential for cancer risk reduction and lifespan extension.
• Discuss approaches to limit DNA damage and enhance repair in normal cells.

Main Methods:

• Literature review of genome maintenance mechanisms.
• Analysis of DNA damage response (DDR) pathways.
• Exploration of therapeutic targeting of DDR and senescence.

Main Results:

• Targeting DNA repair offers therapeutic strategies for cancer.
• Eliminating senescent cells may reduce inflammation.
• Developing methods to limit DNA damage and augment repair in normal cells.

Conclusions:

• Targeting genome maintenance can lower cancer risk.
• Interventions may extend healthy lifespan by preserving somatic genome integrity.
• Future strategies aim to enhance cellular function and longevity through genome maintenance.