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Updated: Jan 15, 2026
Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
Published on: September 11, 2013
Resolution of thrombotic thrombocytopenic purpura serous retinal detachment following rituximab therapy
Maria C Madeira1, João R Romana, Marta R Correia
1Ophthalmology Department, Egas Moniz Hospital, Western Lisbon Local Health Unit (Lisbon - Portugal).
Purpose:
To report a case of bilateral serous retinal detachment occurring early in the course of thrombotic thrombocytopenic purpura (TTP), with a complete and sustained visual and anatomical recovery following rituximab treatment.
Methods:
Clinical and laboratory assessments were performed, supplemented by serial optical coherence tomography imaging. Treatment was pursued with corticotherapy, plasmapheresis and rituximab.
Results:
Vision-threatening serous retinal detachments associated with TTP responded favorably to rituximab, leading to a complete retinal reattachment within one week and full visual recovery within one month.
Conclusion:
Serous retinal detachment should be considered in cases of acute painless visual loss in patients with TTP. Prompt escalation of immunotherapy, particularly rituximab, seems to safeguard excellent visual and anatomical outcomes.
