Next-generation bi-gel platforms for site-specific anticancer delivery

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Oncology

Background:

• Bi-gels are innovative dual-phase systems integrating hydrogels and organogels.
• They facilitate simultaneous delivery of hydrophilic and lipophilic drugs.
• These systems enhance regulated and targeted release of anticancer therapies.

Purpose of the Study:

• To review the principles, composition, and preparation of bi-gels for cancer therapy.
• To explore formulation strategies, targeting mechanisms, and applications in oncology.
• To highlight bi-gels as platforms for enhanced anticancer drug delivery.

Main Methods:

• Examination of bi-gel definition, composition, and gelation processes.
• Analysis of formulation techniques, polymeric materials, and encapsulation parameters.
• Review of targeting strategies (passive, active, microenvironment-responsive) and oncology applications.

Main Results:

• Bi-gels enable efficient encapsulation and phase-controlled drug release.
• They offer tumor-specific targeting through ligand interactions and microenvironment sensitivity.
• Formulation science and therapeutic targeting are combined for improved anticancer effectiveness.

Conclusions:

• Bi-gels represent sophisticated dual-phase drug carriers with significant therapeutic potential.
• They promise enhanced precision and bioavailability in cancer treatment.
• Bi-gels are advanced platforms for regulated drug delivery in oncology.