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Updated: Jan 15, 2026
Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
Published on: January 12, 2019
SURGICAL PROCEDURES PROLONG AMBULATION IN PATIENTS WITH DUCHENNE MUSCULAR DYSTROPHY
David Gonçalves Nordon1, Felipe Cruz Caetano Dos Reis1, Carlos Alberto Dos Santos1
1. Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas (HCFMUSP), Instituto de Ortopedia e Traumatologia, Centro Integrado de Neuro-ortopedia, Sao Paulo, SP, Brazil.
Objective:
The aim of this study was to evaluate the effect of surgical procedures on maintaining ambulation for Duchenne patients.
Methods:
This retrospective cohort study evaluated 35 patients for whom surgery was recommended at our institution from 2012 to 2020.
Results:
Twenty-seven patients were operated on before gait loss, and eight after. In this study, surgical treatment allowed recovery and prolongation of gait for 38.6 months, on average. The sooner the surgery was performed, the better the results were; logistic regression analysis showed that each day of delay after gait loss decreased the chances of success by 0.2%. The optimal interval for intervention was up to 12 months after gait loss.
Conclusion:
Our results thus corroborate the evidence that surgical interventions are beneficial for these patients and suggest a not previously described time window for achieving better outcomes. Level of Evidence lll; Retrospective, Comparative Study of Surgical Interventions.
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