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Photobiomodulation Therapy in Hypertension Management-Evidence from a Systematic Review and Meta-Analysis.
Lara Maria Bataglia Espósito1, Francisco Costa da Rocha1, Praveen R Arany2
1Physical Therapy Department, Federal University of São Carlos (UFSCar), São Carlos, 13565-905, SP, Brazil.
Journal of Clinical Medicine
|October 16, 2025
Summary
Photobiomodulation (PBM) therapy may help manage hypertension by potentially lowering blood pressure (BP) and heart rate (HR). However, current evidence is of very low certainty due to high bias in studies.
Area of Science:
- Cardiovascular Research
- Biomedical Engineering
- Photomedicine
Background:
- Hypertension poses significant health risks, leading to high mortality rates.
- Controlling blood pressure (BP) remains a challenge for many hypertensive patients.
- Photobiomodulation (PBM) therapy is emerging as a potential intervention for hypertension management.
Purpose of the Study:
- To systematically review and meta-analyze existing evidence on PBM therapy's efficacy in managing hypertension.
- To assess the utility of PBM in reducing blood pressure and other cardiovascular parameters.
Main Methods:
- Systematic review and meta-analysis of randomized clinical trials (RCTs) and experimental animal studies.
- Searched five major databases, with data analyzed descriptively and quantitatively.
- Included four RCTs and five experimental studies after screening 197 articles.
Main Results:
- Clinical trials indicated PBM reduced systolic BP (SBP), diastolic BP (DBP), and heart rate (HR) with very low certainty.
- Experimental studies showed PBM reduced SBP, DBP, and mean arterial pressure (MAP), increasing nitric oxide levels, also with very low certainty.
- RCTs exhibited a high risk of bias, while experimental studies had an unclear risk of bias.
Conclusions:
- PBM therapy shows potential as an adjunctive treatment for hypertension, possibly reducing SBP, DBP, MAP, and HR.
- The current evidence supporting PBM for hypertension is of very low certainty.
- Further rigorous, well-designed clinical and experimental studies are required to improve evidence quality.
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