Related Experiment Video

Updated: Jan 15, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

3.2K

Gastroesophageal Reflux Disease (GERD) and Risk of Incident Acute Myocardial Infarction: A Systematic Review and

Tinsae Anebo1, Thitiphan Srikulmontri1, Karecia Byfield1

  • 1Department of Internal Medicine Jefferson Einstein Hospital Philadelphia Pennsylvania USA.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|October 16, 2025
PubMed

Insights

Gastroesophageal reflux disease (GERD) is linked to a higher risk of acute myocardial infarction (AMI). This meta-analysis of over a million participants confirms GERD as a significant risk factor for heart attacks.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Gastroesophageal reflux disease (GERD) is increasingly linked to cardiovascular diseases.
  • The association between GERD and acute myocardial infarction (AMI) requires further clarification.

Purpose of the Study:

  • To systematically review and meta-analyze cohort studies investigating the risk of AMI in individuals with GERD.

Main Methods:

  • A comprehensive search of MEDLINE and EMBASE databases was conducted up to January 2025.
  • Six cohort studies involving 1,324,362 participants were included.
  • Pooled relative risk (RR) was calculated using a random-effects model.

Main Results:

  • Individuals with GERD exhibited a 27% increased risk of incident AMI (pooled RR: 1.27, 95% CI: 1.13-1.47).
  • No significant publication bias was detected.
  • Potential contributing mechanisms include chronic inflammation, oxidative stress, and autonomic dysfunction.

Conclusions:

  • GERD may be a contributing factor to AMI risk.
  • Further research into preventive strategies and targeted interventions for GERD patients is warranted.
  • Exploring mechanistic pathways is crucial for improving patient care and mitigating cardiovascular risk.
Abstract

Keywords:
acute myocardial infraction (AMI)cardiovascular diseasesgastroesophageal reflux disease (GERD)risk factor

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.7K
A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

24.7K

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
1.3K
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
686
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
426
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
209
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
351
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
786