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Updated: Jan 14, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Pd-Catalyzed Enantioselective Double C-H Activation and Transmetalation: Synthesis of
Devendra Parganiha1, Ashwini Dilip Dhumale1, Yagya Dutt Upadhyay1
1Department of Chemistry, Indian Institute of Science Education and Research (IISER) Bhopal, Bhopal By-pass Road, Bhauri, Bhopal, Madhya Pradesh, 462 066, India.
Abstract:
Synthesis of heterocycle-derived chiral ferrocene formaldehydes opens a new avenue for planar chiral ligands, catalysts, and chiral materials. Herein, PdII/MPAA catalyzed enantioselective double C-H activation, an arylation-oxidative deamination strategy, leads to a step-economical synthetic route for regioselective, monoselective, and enantioselective new heterocycle-substituted chiral ferrocene formaldehydes. The developed methodology is quite general to provide indolizinyl, indolyl, pyrrolyl, furanyl, thiophenyl, oxazolyl, thiazolyl, and aryl-substituted platform ferrocene formaldehydes with up to 60% yield and 97:3 er.
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