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Updated: Jan 14, 2026
Investigating Receptor-ligand Systems of the Cellulosome with AFM-based Single-molecule Force Spectroscopy
Published on: December 20, 2013
Direct measurement of SARS-CoV-2 spike RBD binding to integrin αvβ6 by single-molecule force spectroscopy
Tianfu Feng1, Fang Tian1, Jiamin Li1
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Centre (ChemBIC), Nanjing University, Nanjing, P. R. China. pengz@nju.edu.cn.
Abstract:
Single-molecule force spectroscopy reveals strong, cation-dependent binding between SARS-CoV-2 RBD and integrin αvβ6, with rupture forces exceeding those observed for ACE2, supporting integrin αvβ6 as an alternative receptor.
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