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Transcranial Direct Current Stimulation for Online Gamers
Published on: November 9, 2019
Resting-state functional connectivity alterations in intermet gaming disorder: A fMRI study combining voxel-based
Xinyu Wang1, Wenjing Li1, Yimeng Kang1
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China; Key Laboratory for functional magnetic resonance imaging and molecular imaging of Henan Province, Henan Province, China.
Internet gaming disorder (IGD) involves brain alterations in gray matter volume and functional connectivity. These changes in the prefrontal cortex and cingulate gyrus offer insights into adolescent addiction mechanisms.
Area of Science:
- Neuroimaging
- Addiction Research
- Neuroscience
Background:
- Internet gaming disorder (IGD) is recognized as a behavioral addiction.
- Neuroimaging studies indicate gray matter volume alterations and functional connectivity abnormalities in individuals with IGD.
- Understanding the neuropathological mechanisms of IGD is crucial.
Purpose of the Study:
- To investigate structural brain abnormalities in IGD using voxel-based morphometry (VBM).
- To explore resting-state functional connectivity (rs-FC) patterns in IGD.
- To correlate functional connectivity with clinical features of IGD.
Main Methods:
- Systematic literature search (PubMed, Web of Science, Scopus) for VBM studies (2000-2024).
- Anisotropic seed-based D-Mapping (AES-SDM) meta-analysis to compare brain structure between IGDs and healthy controls (HCs).
- rs-FC analysis using meta-derived regions as seeds in 56 IGDs and 43 HCs.
Main Results:
- Reduced gray matter volume (GMV) observed in the prefrontal cortex and cingulate gyrus in IGD.
- Increased GMV noted in the caudate nucleus of individuals with IGD compared to HCs.
- Enhanced rs-FC between the middle cingulate cortex and prefrontal/cingulate/supplementary motor areas in IGD.
Conclusions:
- IGD is associated with dysregulation in cognitive control, reward, and motor networks.
- Prefrontal cortex and cingulate alterations are significant in adolescent addiction.
- Findings provide insights for developing targeted interventions for IGD.
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