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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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The goal of embryo diagnostics and prognostics testing.

Dominique de Ziegler1, Anuja Dokras2, Chelsea Fox3

  • 1Reproductive and Infertility Division, Hospital of Cambodia (Fertility Clinic of Cambodia), Phnom Penh, Kingdom of Cambodia.

Fertility and Sterility
|October 17, 2025
PubMed
Summary
This summary is machine-generated.

Embryo diagnostic and prognostic tests aim to improve IVF outcomes. Current methods lack proven impact on live birth rates, highlighting the need for rigorous validation before clinical use.

Keywords:
Embryo diagnosisembryo prognosticembryo qualitypreimplantation genetic testing (PGT)sustained implantation rates

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • Clinical Genetics

Background:

  • Embryo diagnostic and prognostic tests are widely used in clinical practice.
  • Diagnostic tests identify specific embryo abnormalities, while prognostic tests assess reproductive potential.
  • The ultimate goal is to enhance safety and clinical outcomes in assisted reproductive technologies.

Purpose of the Study:

  • To review the current landscape and clinical utility of embryo diagnostic and prognostic tests.
  • To emphasize the critical need for validation of these preimplantation tests.
  • To discuss the impact of diagnostic versus prognostic tests on live birth rates and clinical efficiency.

Main Methods:

  • Review of current clinical applications of embryo diagnostic and prognostic testing.
  • Analysis of the impact of these tests on cumulative live birth rates and delivery rates per transfer.
  • Discussion of validation requirements for analytical platforms and treatment paradigms.

Main Results:

  • No embryo diagnostic method has been conclusively proven to increase the cumulative live birth rate.
  • Diagnostic tests aim to eliminate affected gestations (e.g., PGT-M, PGT-SR).
  • Prognostic tests aim to improve efficiency by increasing initial delivery rates per transfer without altering cohort potential.

Conclusions:

  • Rigorous validation studies are essential for all preimplantation embryo tests to ensure safety and efficacy.
  • Current diagnostic tests do not improve cumulative live birth rates.
  • Prognostic tests may reduce the burden of care by optimizing embryo selection for transfer.