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Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
Published on: March 28, 2018
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Recent Advances in Primary Biliary Cholangitis Treatment.
Taranika Sarkar Das1, Raj Vuppalanchi2
1The Brooklyn Hospital Center, Department of Gastroenterology and Hepatology, 121 DeKalb Avenue, Brooklyn, NY 11201, USA; NYU Langone Health, 550 1st Avenue, New York, NY 10016, USA.
Clinics in Liver Disease
|October 18, 2025
Summary
Primary biliary cholangitis (PBC) is a rare autoimmune liver disease. Recently approved therapies offer new hope for managing symptoms and improving liver function in patients with this condition.
Area of Science:
- Hepatology
- Autoimmune Diseases
- Pharmacology
Background:
- Primary biliary cholangitis (PBC) is a rare autoimmune liver disease characterized by chronic cholestasis and progressive liver dysfunction.
- Extrahepatic symptoms like pruritus and fatigue significantly impact patient quality of life.
Purpose of the Study:
- To review recently approved therapies for primary biliary cholangitis (PBC).
- To discuss the clinical application and nuances of these new treatments.
- To explore the future landscape of novel investigational therapies for PBC.
Main Methods:
- Literature review of recently approved and investigational treatments for PBC.
- Analysis of clinical trial data and guidelines for current therapies.
- Discussion of emerging therapeutic targets and strategies.
Main Results:
- Ursodeoxycholic acid remains the first-line therapy.
- Second-line options include obeticholic acid, with recent approvals of seladelpar and elafibranor.
- These therapies aim to improve liver function and alleviate symptoms.
Conclusions:
- Newer agents like seladelpar and elafibranor expand treatment options for PBC.
- Careful consideration of individual patient profiles is crucial for optimal treatment selection.
- Ongoing research into novel therapies promises further advancements in PBC management.
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