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Biologic therapies for dermatologic emergencies: A comprehensive review
Nina Modanlo1, Kyle Cheng2, Michael O Nguyen2
1David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Journal of the American Academy of Dermatology
|October 19, 2025
Summary
Biologic medications offer targeted treatment for severe skin conditions like Stevens-Johnson syndrome, potentially improving outcomes. These advanced therapies provide a focused alternative to broad immunosuppression for dermatologic emergencies.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Dermatologic emergencies involve severe immune system overactivation.
- Traditional treatments include supportive care, trigger avoidance, and systemic immunosuppression.
- These methods aim to reduce illness and death but can have significant side effects.
Purpose of the Study:
- To review the use of biologic medications in managing acute dermatologic emergencies.
- To provide practical guidance for inpatient dermatologists.
- To highlight biologics as a targeted therapeutic option.
Main Methods:
- Literature review of studies on biologics in dermatologic emergencies.
- Focus on specific conditions: drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), pemphigus vulgaris (PV), and generalized pustular psoriasis (GPP).
- Analysis of immune pathways targeted by biologics.
Main Results:
- Biologic medications target specific inflammatory pathways involved in dermatologic emergencies.
- They offer a more focused approach compared to systemic immunosuppression.
- Potential for reduced systemic toxicity and improved patient outcomes.
Conclusions:
- Biologics represent a significant advancement in treating acute dermatologic emergencies.
- Their targeted action provides an alternative to broad immunosuppression.
- Increasing understanding of disease mechanisms will likely expand the role of biologics in managing these critical conditions.
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