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Design and Fabrication of In-House Nozzle System to Extrude Multi-Hydrogels for 3D Bioprinting Process
Ahasan Habib1, Connor Quigley1, Rokeya Sarah1
1Keene State College, 229 Main Street, TDS Center, Room 121, Keene, NH 03435.
Journal of Manufacturing Science and Engineering
|October 20, 2025
Summary
Researchers developed a reusable 3D bioprinting nozzle system with adjustable angles to precisely control material flow and minimize switching time for creating functional tissues.
Area of Science:
- Bioprinting and Tissue Engineering
- Materials Science
Background:
- 3D bioprinting aims to create functional tissues for medical applications.
- Precise control over multi-material deposition with distinct cells remains a challenge.
Purpose of the Study:
- To present an updated, reusable Y-shaped nozzle connector system for 3D bioprinting.
- To investigate the effect of varying internal angles on material switching time and backflow control.
Main Methods:
- Fabrication of stainless steel nozzle connectors with adjustable angles (30°, 45°, 60°, 90°).
- Testing the nozzle system with a hybrid hydrogel (alginate-carboxymethyl cellulose).
- Measurement and comparison of material switching times across different angles.
Main Results:
- The stainless steel nozzle connectors are reusable, sterile, and easy to clean.
- Adjustable angles influence backflow control and minimize material switching time.
- The system facilitates user-defined material distribution in 3D bioprinting.
Conclusions:
- The updated nozzle system offers improved control and efficiency for multi-material 3D bioprinting.
- This advancement supports the development of complex, functional engineered tissues.
- The reusable design enhances practicality and sustainability in bioprinting research.
