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Updated: Jan 14, 2026
07:23
Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
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SYSTEMIC THROMBOEMBOLIC OUTCOMES IN YOUNG PATIENTS AFTER RETINAL VEIN OCCLUSIONS
Charles Zhang1,2, Mohammad Ayoubi3, Jonathan B Lin4
1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida.
Retina (Philadelphia, Pa.)
|October 23, 2025
Summary
Young patients experiencing retinal vein occlusions (RVO) face a higher risk of developing venous thromboembolism and stroke, even without traditional risk factors. This study highlights the need for vigilance in these cases.
Area of Science:
- Ophthalmology
- Vascular Medicine
- Thrombosis Research
Background:
- Retinal vein occlusion (RVO) can be a manifestation of underlying systemic conditions.
- Identifying hypercoagulable complications in young RVO patients is crucial for long-term health management.
- Previous studies have not fully elucidated the long-term risks in young RVO patients with negative initial workups.
Purpose of the Study:
- To assess the long-term incidence of hypercoagulable complications in young patients diagnosed with RVO.
- To compare the risk of thrombotic events in RVO patients versus matched controls without RVO.
- To investigate specific outcomes including deep vein thrombosis, pulmonary embolism, and cerebral infarction.
Main Methods:
- A retrospective cohort study utilizing the TriNetX Analytics Network.
- Inclusion of patients aged 18-50 with newly diagnosed RVO and exclusion of those with known risk factors (hypertension, glaucoma, thrombophilia, oral contraceptive use).
- Propensity score matching (PSM) to create comparable RVO and control cohorts, followed by analysis of cumulative incidence and risk ratios over 1, 3, and 5 years.
Main Results:
- Propensity score matching included 2,731 patients in both the RVO and control groups.
- Patients with RVO demonstrated significantly higher cumulative incidence of venous thromboembolism, cerebral infarction, and composite embolic events at 1, 3, and 5 years (p < 0.0001).
- No statistically significant differences in the rates of myocardial infarction or composite cardiovascular events were observed between the groups.
Conclusions:
- Young patients with RVO, even with negative initial hypercoagulable workups, are at a substantially increased risk for venous thrombosis and stroke.
- The findings underscore the importance of considering RVO as a potential indicator of prothrombotic states in younger individuals.
- Myocardial infarction risk does not appear to be elevated in this specific young RVO cohort.
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