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Risk Factors for Delirium in Trauma Elderly Patients: An Analysis Using the National Trauma Data Bank From 2021 to
Jose Euberto Mendez Reyes1, Travis J Miles1, Catherine Seger1
1Department of Surgery, Baylor College of Medicine, Houston, Texas.
The Journal of Surgical Research
|October 23, 2025
Summary
Delirium is underdiagnosed in elderly trauma patients. Key risk factors include dementia, dependency, bleeding disorders, and male sex, while Hispanic ethnicity shows lower odds, suggesting potential diagnostic disparities.
Area of Science:
- Geriatric Medicine
- Trauma Surgery
- Neuroscience
Background:
- Delirium is a prevalent, serious, and often underdiagnosed condition in elderly hospitalized patients.
- Adverse outcomes are associated with delirium, highlighting the need for better understanding in specific populations.
- There is a critical knowledge gap regarding delirium risk factors in trauma patients.
Purpose of the Study:
- To identify and analyze the risk factors associated with delirium in elderly trauma patients.
- To investigate the prevalence and predictors of delirium in this demographic.
- To inform strategies for improved recognition, prevention, and management of delirium in trauma care.
Main Methods:
- Utilized the National Trauma Data Bank (2021-2022) for a cohort of patients aged 65 and above.
- Employed descriptive statistics to characterize the study population and assess crude associations.
- Conducted logistic regression analysis to determine significant risk factors for delirium.
Main Results:
- The study included 822,591 elderly trauma patients, with a delirium prevalence of 2.3%.
- Significant risk factors for delirium included a history of dementia (OR 1.67), functional dependency (OR 1.61), bleeding disorder (OR 1.60), and male sex (OR 1.49).
- Hispanic ethnicity was associated with lower delirium odds (OR 0.53), and transfer from another facility was not a significant independent factor.
Conclusions:
- Delirium appears underdiagnosed in elderly trauma patients, evidenced by low documented prevalence.
- Identified risk factors, particularly variations by sex and ethnicity, may point to diagnostic disparities.
- Enhanced detection across diverse populations is crucial for reducing delirium incidence, severity, and improving patient outcomes.

