Chronic Urticaria: Current Status and New Therapeutic Perspectives - A Clinical Review

This article examines current and emerging therapeutic perspectives in chronic urticaria management. It describes the established stepwise therapeutic algorithm, from second-generation H1-antihistamines to cyclosporine, emphasizing the importance of continuous administration and periodic evaluation. The article analyzes emerging therapies, including BTK inhibitors, new specific receptor antagonists, and biological therapies, which promise more targeted and personalized options. The evolution toward treatments based on specific disease mechanisms is highlighted, offering hope for patients refractory to conventional therapies. Recent developments in understanding molecular mechanisms have led to novel therapeutic approaches that address different aspects of mast cell activation and inflammatory cascades.