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Updated: Jan 14, 2026
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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
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Are We Ready With Prevention for Type 1 Diabetes?
Evelina Maines1, Roberto Franceschi2, Francesca di Candia3
1Department of Pediatrics, S. Chiara Hospital of Trento, APSS, Trento, Italy.
Diabetes/Metabolism Research and Reviews
|October 25, 2025
Summary
Preventing type 1 diabetes (T1D) is advancing with new disease-modifying therapies. While teplizumab delays Stage 3 T1D onset, research continues to optimize treatments for halting beta-cell destruction.
Area of Science:
- Immunology
- Endocrinology
- Pediatrics
Background:
- Type 1 diabetes (T1D) prevention remains a challenge, but disease-modifying therapies offer new hope.
- Understanding T1D progression is crucial for developing effective interventions.
Purpose of the Study:
- To review current knowledge on T1D prevention in youth using disease-modifying therapies.
- To summarize therapies targeting different stages of T1D.
Main Methods:
- A narrative literature review was conducted.
- PubMed/MEDLINE database was searched using keywords: 'screening', 'prevention', 'Disease-modifying therapy', and 'Diabetes Mellitus, Type 1' in youth (0-18 years).
Main Results:
- Teplizumab is the first FDA-approved drug to delay Stage 3 T1D onset.
- Various agents (monoclonal antibodies, cytokine inhibitors, antigen-specific therapies) are under investigation.
- Interventions in Stage 3 T1D show temporary beta-cell function improvement, but benefits are short-lived.
Conclusions:
- Disease-modifying therapies represent a new era in T1D management, aiming to halt progression.
- Further research is essential to refine patient selection, identify new targets, and optimize immunotherapy timing and durability.
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