Related Experiment Video
Updated: Jan 14, 2026

Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
HPV vaccination is associated with lower risk of cancers among females
Yao-Min Hung1, Ting-An Lin2, Shiow-Ing Wang3
1Division of Nephrology, Department of Internal Medicine, Taitung Hospital, Ministry of Health and Welfare, Taitung, Taiwan; Master of Biomedicine Program, College of Science and Engineering, National Taitung University, Taitung, Taiwan; College of Health and Nursing, Meiho University, Pingtung, Taiwan; Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Background:
HPV vaccines prevent certain cancers, but the broader long-term effects are unclear. We assessed whether HPV vaccination is associated with cancer risk among females aged 9-26 years.
Methods:
Retrospective cohort study in the TriNetX U.S. Collaborative Network (Jan 1, 2013-Dec 31, 2022) comparing HPV-vaccinated versus unvaccinated females after 1:1 PSM; Cox proportional-hazards models estimated HRs (95% CIs), with subgroup analyses by age, race/ethnicity, and vaccine valence, and sensitivity analyses using active comparators (influenza- and HBV-vaccinated) and a health check-up cohort.
Results:
The findings showed that HPV vaccination was significantly associated with overall cancer risk (HR 0.38, 95% CI 0.34-0.42), with greater reduction when initiated at ages 9-14 versus 15-26 (HR 0.37 versus 0.54). Both 9vHPV and 4vHPV vaccines lowered cancer risks, with consistent support from sensitivity analyses.
Conclusions:
In this multi-institutional retrospective cohort, HPV vaccination was associated with lower incidence of several cancers among females aged 9-26 years.
More Related Videos
10:26RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
07:43Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples
Published on: July 29, 2017
Related Concept Videos
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Prevention
Some...
Mechanisms of Retrovirus-induced Cancers
Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
Disorders of the Female Reproductive System
Cancer