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Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...
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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
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Oral Cavity Involvement in Mucormycosis: A Systematic Review.

Krithika Chandrasekaran1, Sridhar Chitathoor2, Ashwini Deshpande3

  • 1Oral Medicine and Radiology, Meenakshi Ammal Dental College, Meenakshi Academy of Higher Education and Research, Chennai, India.

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|October 27, 2025
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Summary

Oral mucormycosis, a dangerous fungal infection, is often missed. Early diagnosis and treatment, especially in post-COVID-19 diabetic patients, are crucial for better outcomes.

Keywords:
amphotericin Bantifungal agentsdiabetes mellitusfungal infectionsmaxillapalate

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Oral Medicine

Background:

  • Mucormycosis is a rare, life-threatening fungal infection.
  • Oral cavity involvement is underreported and misdiagnosed.
  • It can progress rapidly with severe complications.

Purpose of the Study:

  • To systematically review clinical presentation, diagnosis, and management of oral mucormycosis.
  • To synthesize evidence on anatomical patterns and outcomes.
  • To evaluate treatment strategies for oral mucormycosis.

Main Methods:

  • Systematic literature search across major databases.
  • Included 7 human studies with 451 cases.
  • Data synthesized narratively; quality assessed using Newcastle-Ottawa Scale and ROBINS-I.

Main Results:

  • Most affected were middle-aged males with diabetes, often post-COVID-19.
  • Common signs: palatal ulcers, eschar, tooth mobility, necrotic lesions.
  • Diagnosis via KOH mount, histopathology, imaging; treated with Amphotericin B and surgery.

Conclusions:

  • Oral mucormycosis is critical and underrecognized.
  • Timely identification in high-risk individuals is vital.
  • Early diagnosis and combined treatment improve outcomes.