Interplay between acute Type A aortic dissection and pan-cancer: Clinical evidence, bioinformatics, and experimental...

Area of Science:

• Cardiovascular Research
• Oncology
• Molecular Biology

Background:

• Acute Type A Aortic Dissection (ATAAD) and various cancers pose significant global health challenges.
• Epidemiological studies suggest a potential link between ATAAD and increased incidence of lung adenocarcinoma (LUAD) and head and neck squamous cell carcinoma (HNSCC).

Purpose of the Study:

• To investigate shared molecular mechanisms between ATAAD and cancer.
• To identify potential biomarkers and therapeutic targets common to both conditions.

Main Methods:

• Integrated multi-omics analysis to identify key molecular players.
• Epidemiological data analysis to assess cancer risk associated with ATAAD.
• Functional assays in cancer cell lines (LUAD, HNSCC) to validate molecular findings.

Main Results:

• Mitochondrial peptidylprolyl isomerase F (PPIF) was identified as a key biomarker for ATAAD, significantly overexpressed in monocytes.
• PPIF overexpression was found to correlate with poor prognosis across multiple cancer types.
• Functional studies confirmed that PPIF promotes proliferation, migration, and invasion in LUAD and HNSCC cells.

Conclusions:

• PPIF acts as a shared mechanistic link between ATAAD pathogenesis and cancer progression.
• PPIF represents a potential therapeutic target for both ATAAD and associated malignancies.